raltitrexed
(IVTVGDXNLFLDRM-HNNXBMFYSA-N)
Structure
- SMILES
- OC(=O)CC[C@@H](C(=O)O)NC(=O)c1ccc(s1)N(Cc1ccc2c(c1)c(=O)[nH]c(n2)C)C
- Type(s)
- Approved; Investigational
- ATC code(s)
- L01BA03
- Molecular Formula:
- C21H22N4O6S
- Molecular Weight:
- 458.488
- Log P:
- 2.3681
- Hydrogen Bond Acceptor:
- 10
- Hydrogen Bond Donor:
- 4
- TPSA:
- 180.93
- CAS Number(s):
- 112887-68-0
Synonym(s)
1.
raltitrexed
2.
D 1694
3.
D-1694
4.
D1694
5.
ICI D1694
6.
ICI-D1694
7.
N-(5-(N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino)-2-thenoyl)-L-glutamic acid
8.
Tomudex
9.
ZD 1694
10.
ZD-1694
11.
ZD1694
External Link(s)
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Abdominal Pain | SIDER | ||
| 2 | Adenocarcinoma | 12698181 | CTD | |
| 3 | Alopecia | SIDER | ||
| 4 | Anemia | 11528249 | CTD | |
| 5 | Anorexia | 11528249 | CTD SIDER | |
| 6 | Arthralgia | SIDER | ||
| 7 | Asthenia | SIDER | ||
| 8 | Atrial Fibrillation | SIDER | ||
| 9 | Cellulitis | SIDER | ||
| 10 | Colorectal Neoplasms | 11528249 21301589 | CTD | |
| 11 | Conjunctivitis | SIDER | ||
| 12 | Constipation | SIDER | ||
| 13 | Dehydration | SIDER | ||
| 14 | Dermatitis | SIDER | ||
| 15 | Diarrhea | 11528249 | CTD | |
| 16 | Discomfort | SIDER | ||
| 17 | Dysgeusia | SIDER | ||
| 18 | Dyspepsia | SIDER | ||
| 19 | Extravasation | SIDER | ||
| 20 | Fatigue | 11528249 | CTD | |
| 21 | Febrile Neutropenia | SIDER | ||
| 22 | Feeling abnormal | SIDER | ||
| 23 | Gastrointestinal Pain | SIDER | ||
| 24 | Headache | SIDER | ||
| 25 | Infection | SIDER | ||
| 26 | Influenza-like symptoms | SIDER | ||
| 27 | Leukopenia | SIDER | ||
| 28 | Malaise | SIDER | ||
| 29 | Mesothelioma | 21645609 | CTD | |
| 30 | Musculoskeletal discomfort | SIDER | ||
| 31 | Nausea | SIDER | ||
| 32 | Necrosis | SIDER | ||
| 33 | Neoplasms | 1931603 | CTD | |
| 34 | Neurologic Manifestations | 11528249 | CTD | |
| 35 | Neutropenia | 11528249 | CTD SIDER | |
| 36 | Pain | SIDER | ||
| 37 | Pruritus | SIDER | ||
| 38 | Sepsis | SIDER | ||
| 39 | Sinus Tachycardia | SIDER | ||
| 40 | Stomatitis | SIDER | ||
| 41 | Supraventricular tachycardia | SIDER | ||
| 42 | Sweating | SIDER | ||
| 43 | Thrombocytopenia | 11528249 | CTD SIDER | |
| 44 | Vomiting | SIDER | ||
| 45 | Weight decreased | SIDER |
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