MetaADEDB 2.0 @ LMMD
Dexrazoxane
(BMKDZUISNHGIBY-ZETCQYMHSA-N)
Structure
SMILES
O=C1NC(=O)CN(C1)C[C@@H](N1CC(=O)NC(=O)C1)C
Type(s)
Approved; Withdrawn
ATC code(s)
V03AF02
Molecular Formula:
C11H16N4O4
Molecular Weight:
268.269
Log P:
-2.1749
Hydrogen Bond Acceptor:
8
Hydrogen Bond Donor:
2
TPSA:
98.82
CAS Number(s):
24584-09-6
Synonym(s)
1.
Dexrazoxane
2.
ADR-529
3.
Cardioxan
4.
Cardioxane
5.
Dexrazoxane Hydrochloride
6.
ICRF-187
7.
NSC-169780
8.
Razoxane, (S)-Isomer
9.
Razoxane, (S)-Isomer, Hydrochloride
10.
Zinecard
11.
ADR 529
12.
ADR529
13.
Hydrochloride, Dexrazoxane
14.
ICRF 187
15.
ICRF187
16.
NSC 169780
17.
NSC169780
External Link(s)
MeSHD064730
PubChem Compound71384
ChEBI50223
CHEMBLCHEMBL1738
DrugBankDB00380
DrugCentral839
IUPHAR/BPS Guide to PHARMACOLOGY7330
KEGGdr:D03730
Therapeutic Target DatabaseD07XVN
D0X3ST
ZINC87515509
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug ineffectiveFAERS: 4US FAERS
2Drug administration errorFAERS: 2OFFSIDES
US FAERS
3Drug dose omissionFAERS: 2US FAERS
4ExtravasationFAERS: 2SIDER
US FAERS
5Burning sensationFAERS: 1US FAERS
6Drug ineffective for unapproved indicationFAERS: 1US FAERS
7Ejection Fraction DecreasedFAERS: 1US FAERS
8ErythemaFAERS: 1SIDER
US FAERS
9Infusion Site ExtravasationFAERS: 1OFFSIDES
US FAERS
10Infusion site irritationFAERS: 1US FAERS
11Injection site phlebitisFAERS: 1SIDER
US FAERS
12Muscle tightnessFAERS: 1US FAERS
13NauseaFAERS: 1SIDER
US FAERS
14NecrosisFAERS: 1US FAERS
15No adverse eventFAERS: 1US FAERS
16Product use in unapproved indicationFAERS: 1US FAERS
17Product use issueFAERS: 1US FAERS
18Respiratory arrestFAERS: 1US FAERS
19Sinus bradycardiaFAERS: 1US FAERS
20ThrombocytopeniaFAERS: 1SIDER
US FAERS
21Treatment related secondary malignancyFAERS: 1US FAERS
22Unresponsive to stimuliFAERS: 1US FAERS
23VomitingFAERS: 1SIDER
US FAERS
24Weight decreasedFAERS: 1SIDER
US FAERS
25Abdominal PainSIDER
26Abdominal symptomOFFSIDES
27AcidosisOFFSIDES
28AgranulocytosisSIDER
29AgraphiaOFFSIDES
30Alanine Aminotransferase IncreasedSIDER
31AlopeciaSIDER
32AngioplastyOFFSIDES
33AnorexiaSIDER
34Aspartate Aminotransferase IncreasedSIDER
35AstheniaSIDER
36AtaxiaOFFSIDES
37AuraOFFSIDES
38AutomatismOFFSIDES
39Bacterial sepsisOFFSIDES
40BlepharospasmOFFSIDES
41Blood alkaline phosphatase increasedSIDER
42Blood and lymphatic system disordersSIDER
43Blood creatinine increasedSIDER
44Blood lactate dehydrogenase increasedSIDER
45Blood sodiumOFFSIDES
46Brain scan abnormalOFFSIDES
47Ca++ increasedSIDER
48Carcinoembryonic antigen increasedOFFSIDES
49Cardiac ventricular disorderOFFSIDES
50Cardiotoxicity26873546CTD
SIDER
51Cerebral disorderOFFSIDES
52ConstipationSIDER
53Creatinine increasedSIDER
54DehydrationOFFSIDES
55Depressed Level of ConsciousnessOFFSIDES
56Device related infectionOFFSIDES
57Dihydropyrimidine Dehydrogenase DeficiencyOFFSIDES
58DiscomfortSIDER
59Disease ProgressionSIDER
60DizzinessSIDER
61DrowsinessOFFSIDES
62EncephalitisOFFSIDES
63Epstein-Barr virus associated lymphoproliferative disorderOFFSIDES
64Excessive eye blinkingOFFSIDES
65Fanconi SyndromeOFFSIDES
66FatigueSIDER
67Febrile NeutropeniaSIDER
68Feeling abnormalSIDER
69GangreneOFFSIDES
70Gastrointestinal PainSIDER
71GlobulinuriaOFFSIDES
72Graft infectionOFFSIDES
73HeadacheSIDER
74Heart Injuries30517846CTD
75Heart failure23831762CTD
76HypercreatininaemiaOFFSIDES
77HyperventilationOFFSIDES
78InfectionSIDER
79InfestationSIDER
80Infusion site burningSIDER
81Infusion site painSIDER
82Injection Site ReactionSIDER
83Injection site erythemaSIDER
84Injection site painSIDER
85Kidney FailureOFFSIDES
86Lactic dehydrogenase activity increasedSIDER
87Leukopenia neonatalOFFSIDES
88LeukopeniaSIDER
89MalaiseSIDER
90MalnutritionSIDER
91Metabolic acidosisOFFSIDES
92Muscle necrosisOFFSIDES
93Musculoskeletal discomfortSIDER
94MyalgiaSIDER
95MyelosuppressionSIDER
96MyotoniaOFFSIDES
97NeutropeniaSIDER
98Neutropenic infectionSIDER
99PainSIDER
100Pancreatic enzymes increasedOFFSIDES
101PancytopeniaSIDER
102PhlebitisSIDER
103Pneumocystis jiroveci pneumoniaOFFSIDES
104PneumoniaSIDER
105Post procedural infectionSIDER
106Postoperative infectionSIDER
107PruritusSIDER
108Pulmonary HypertensionOFFSIDES
109Renal tubular disorderOFFSIDES
110Reticulocyte count decreasedOFFSIDES
111Retinoic acid syndromeOFFSIDES
112SepsisSIDER
113ShockSIDER
114Sodium decreasedSIDER
115SomnolenceSIDER
116StaringOFFSIDES
117StomatitisSIDER
118SyncopeSIDER
119Testicular Diseases30517846CTD
120Transaminases increasedOFFSIDES
121TremorSIDER
122UrticariaSIDER
123Venous thrombosis limbSIDER
124Ventricular Dysfunction, Left23831762CTD
125Viral myositisOFFSIDES
126White blood cell count decreasedSIDER
127Wound ComplicationSIDER
128nervous system disorderSIDER
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