MetaADEDB is an online database we developed to integrate comprehensive information of adverse drug events (ADEs).
Adverse drug event (ADE) is defined as an injury during medication administration related to medicine, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. ADEs lead to an enormous amount of morbidity and mortality. Previous studies showed that about 6% of patients were hospitalized due to ADE in the U.S., and ADEs caused 197,000 deaths in Europe per year. The more People usually take medicines as they age, the more the risk of adverse events may take place. The good news is the most of ADEs are preventable. So reducing adverse drug events is urgent to detect or determine ADEs and prevent the occurrence of ADEs.
The new version consists of 744,709 drug-ADE associations between 8,498 compounds (including more than 3000 drugs) and 13,193 ADEs by integrating more and newer data from U.S. FDA Adverse Event Reporting System (FAERS) and Canada Vigilance Adverse Reaction Online Data-base in addition to the Comparative Toxicogenomics Database (CTD), SIDER and OFFSIDES. Additionally, Compared to the previous version, MetaADEDB 2.0 has an over 40% increase in drug-ADE associations and almost 200% growth in the total number of compounds. Notably, we directly generated a unique identifier for each compound based on the chemical structure, and UMLS ID was used as unique identifier for ADE to ensure the quality of data.
Three concepts about adverse effect: