MetaADEDB 2.0 @ LMMD
nusinersen
(WWFDJIVIDXJAQR-FFWSQMGZSA-N)
Structure
SMILES
COCCO[C@@H]1[C@H](OP(=S)(OC[C@H]2O[C@H]([C@@H]([C@@H]2OP(=S)(OC[C@H]2O[C@H]([C@@H]([C@@H]2OP(=S)(OC[C@H]2O[C@H]([C@@H]([C@@H]2OP(=S)(OC[C@H]2O[C@H]([C@@H]([C@@H]2OP(=S)(OC[C@H]2O[C@H]([C@@H]([C@@H]2OP(=S)(OC[C@H]2O[C@H]([C@@H]([C@@H]2OP(=S)(OC[C@H]2O[C@H]([C@@H]([C@@H]2OP(=S)(OC[C@H]2O[C@H]([C@@H]([C@@H]2OP(=S)(OC[C@H]2O[C@H]([C@@H]([C@@H]2O)OCCOC)n2cnc3c2nc(N)[nH]c3=O)O)OCCOC)n2cnc3c2nc(N)[nH]c3=O)O)OCCOC)n2cc(C)c(=O)[nH]c2=O)O)OCCOC)n2cc(C)c(nc2=O)N)O)OCCOC)n2cnc3c2nc(N)[nH]c3=O)O)OCCOC)n2cc(C)c(=O)[nH]c2=O)O)OCCOC)n2cnc3c2ncnc3N)O)OCCOC)n2cnc3c2ncnc3N)O)OCCOC)n2cc(C)c(=O)[nH]c2=O)O)[C@H](O[C@H]1n1cnc2c1ncnc2N)COP(=S)(O[C@@H]1[C@@H](COP(=S)(O[C@@H]2[C@@H](COP(=S)(O[C@@H]3[C@@H](COP(=S)(O[C@@H]4[C@@H](COP(=S)(O[C@@H]5[C@@H](COP(=S)(O[C@@H]6[C@@H](COP(=S)(O[C@@H]7[C@@H](COP(=S)(O[C@@H]8[C@@H](CO)O[C@H]([C@@H]8OCCOC)n8cc(C)c(=O)[nH]c8=O)O)O[C@H]([C@@H]7OCCOC)n7cc(C)c(nc7=O)N)O)O[C@H]([C@@H]6OCCOC)n6cnc7c6ncnc7N)O)O[C@H]([C@@H]5OCCOC)n5cc(C)c(nc5=O)N)O)O[C@H]([C@@H]4OCCOC)n4cc(C)c(=O)[nH]c4=O)O)O[C@H]([C@@H]3OCCOC)n3cc(C)c(=O)[nH]c3=O)O)O[C@H]([C@@H]2OCCOC)n2cc(C)c(=O)[nH]c2=O)O)O[C@H]([C@@H]1OCCOC)n1cc(C)c(nc1=O)N)O
Molecular Formula:
C234H340N61O128P17S17
Molecular Weight:
7127.190
Log P:
8.4660
Hydrogen Bond Acceptor:
196
Hydrogen Bond Donor:
40
TPSA:
3083.82
CAS Number(s):
1258984-36-9
Synonym(s)
1.
nusinersen
2.
ASO-10-27
3.
ISIS 396443
4.
ISIS-SMN(Rx)
5.
ISIS-SMNRx
6.
SPINRAZA
External Link(s)
MeSHC000590926
PubChem Compound131801471
124037382
IUPHAR/BPS Guide to PHARMACOLOGY9416
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Lower respiratory tract infectionFAERS: 2US FAERS
2Acute respiratory failureFAERS: 1US FAERS
3AstheniaFAERS: 1US FAERS
4Bilevel positive airway pressureFAERS: 1US FAERS
5Drug ineffectiveFAERS: 1US FAERS
6Human bocavirus infectionFAERS: 1US FAERS
7InfectionFAERS: 1US FAERS
8MeningitisFAERS: 1US FAERS
9NystagmusFAERS: 1US FAERS
10Optic AtrophyFAERS: 1US FAERS
11PneumothoraxFAERS: 1US FAERS
12ProteinuriaFAERS: 1US FAERS
13Respiratory FailureFAERS: 1US FAERS
14Respiratory arrestFAERS: 1US FAERS
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