MetaADEDB 2.0 @ LMMD
tipifarnib
(PLHJCIYEEKOWNM-HHHXNRCGSA-N)
Structure
SMILES
Clc1ccc(cc1)[C@](c1cncn1C)(c1ccc2c(c1)c(cc(=O)n2C)c1cccc(c1)Cl)N
Type(s)
Investigational
Molecular Formula:
C27H22Cl2N4O
Molecular Weight:
489.396
Log P:
6.1967
Hydrogen Bond Acceptor:
5
Hydrogen Bond Donor:
1
TPSA:
65.84
CAS Number(s):
192185-72-1
Synonym(s)
1.
tipifarnib
2.
(R)-6-(amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone
3.
2 (1H))-quinolinone,6-(amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methyl-,(+)-
4.
R 115777
5.
R-115777
6.
R115777
7.
Zarnestra
External Link(s)
MeSHC402769
PubChem Compound159324
BindingDB50370385
ChEBI141969
CHEMBLCHEMBL289228
DrugBankDB04960
IUPHAR/BPS Guide to PHARMACOLOGY8025
KEGGdr:D03720
Therapeutic Target DatabaseD07NPS
ZINC24809155
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1NeutropeniaFAERS: 1US FAERS
2Colonic Neoplasms15970518CTD
3Inflammation24073415CTD
4Lung Neoplasms16733249CTD
5Mammary Neoplasms, Experimental16648579CTD
6Multiple Myeloma15728126CTD
7Neoplasms, Experimental17876043CTD
8Skin Neoplasms15970518CTD
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