MetaADEDB 2.0 @ LMMD
manidipine
(ANEBWFXPVPTEET-UHFFFAOYSA-N)
Structure
SMILES
COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN1CCN(CC1)C(c1ccccc1)c1ccccc1)C
Type(s)
Approved; Investigational
ATC code(s)
C08CA11; C09BB12
Molecular Formula:
C35H38N4O6
Molecular Weight:
610.699
Log P:
5.6808
Hydrogen Bond Acceptor:
7
Hydrogen Bond Donor:
1
TPSA:
116.93
CAS Number(s):
89226-50-6; 120092-68-4
Synonym(s)
1.
manidipine
2.
2-(4-diphenylmethyl-1-piperazinyl)ethyl methyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
3.
CV 4093
4.
CV-4093
5.
manidipine dihydrochloride
6.
manidipine hydrochloride
7.
manidipine, (+-)-isomer
External Link(s)
MeSHC054218
PubChem Compound4008
BindingDB50227969
ChEBI135849
CHEMBLCHEMBL312176
CHEMBL1085699
DrugBankDB09238
DrugCentral1631
KEGGdr:D08155
Therapeutic Target DatabaseD08TVA
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1AbasiaOFFSIDES
2Abdominal tendernessOFFSIDES
3Accidental overdoseOFFSIDES
4AkinesiaOFFSIDES
5Alanine Aminotransferase IncreasedOFFSIDES
6Altered state of consciousnessOFFSIDES
7AmphetaminesOFFSIDES
8ApathyOFFSIDES
9AscitesOFFSIDES
10Aspiration PneumoniaOFFSIDES
11AstheniaOFFSIDES
12AutomatismOFFSIDES
13BalanitisOFFSIDES
14Band neutrophil percentage increasedOFFSIDES
15Basophil percentage decreasedOFFSIDES
16Bilirubin conjugated increasedOFFSIDES
17Blood alkaline phosphatase increasedOFFSIDES
18Blood amylase increasedOFFSIDES
19Blood creatine phosphokinase increasedOFFSIDES
20Blood creatinine increasedOFFSIDES
21Blood glucose abnormalOFFSIDES
22Blood glucose decreasedOFFSIDES
23Blood lactate dehydrogenase increasedOFFSIDES
24Blood sodiumOFFSIDES
25Blood urea increasedOFFSIDES
26BradycardiaOFFSIDES
27Catalepsy8794996
9533112		CTD
28Cerebral artery stenosisOFFSIDES
29CholangiolitisOFFSIDES
30ChromaturiaOFFSIDES
31Cytomegalovirus antibody positiveOFFSIDES
32DehydrationOFFSIDES
33Depressed Level of ConsciousnessOFFSIDES
34DiarrheaOFFSIDES
35DrowsinessOFFSIDES
36Duodenal UlcerOFFSIDES
37DysphoniaOFFSIDES
38Dyspnoea exacerbatedOFFSIDES
39EczemaOFFSIDES
40Electrocardiogram R on T phenomenonOFFSIDES
41Electromechanical dissociationOFFSIDES
42EnteritisOFFSIDES
43EnterocolitisOFFSIDES
44EnuresisOFFSIDES
45Eosinophil percentage decreasedOFFSIDES
46ErythemaOFFSIDES
47ExcoriationOFFSIDES
48Gamma-Glutamyltransferase IncreasedOFFSIDES
49Gaze palsyOFFSIDES
50General physical health deteriorationOFFSIDES
51GlobulinuriaOFFSIDES
52Ileal ulcerOFFSIDES
53IncoherentOFFSIDES
54Infusion site painOFFSIDES
55Intestinal ObstructionOFFSIDES
56Intestinal mucosal hypertrophyOFFSIDES
57Intracranial AneurysmOFFSIDES
58Kidney FailureOFFSIDES
59Lack of spontaneous speechOFFSIDES
60Long QT SyndromeOFFSIDES
61Lymphocyte percentage decreasedOFFSIDES
62Lymphocyte stimulation test positiveOFFSIDES
63Meningioma surgeryOFFSIDES
64Musculoskeletal stiffnessOFFSIDES
65Myoglobin blood increasedOFFSIDES
66Nephrotic SyndromeOFFSIDES
67Oculomucocutaneous syndromeOFFSIDES
68OliguriaOFFSIDES
69Oropharyngeal discomfortOFFSIDES
70PancreatitisOFFSIDES
71Peripheral nerve palsyOFFSIDES
72PhlebitisOFFSIDES
73Pulmonary InfarctionOFFSIDES
74Rectal fissureOFFSIDES
75RhabdomyolysisOFFSIDES
76SchizophreniaOFFSIDES
77Sick Sinus SyndromeOFFSIDES
78Staphylococcal abscessOFFSIDES
79Supraventricular tachycardiaOFFSIDES
80Tachycardia8781749CTD
81Transaminases increasedOFFSIDES
82Ventricular FibrillationOFFSIDES
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