AptaDB
AptaDB is an online database that integrated comprehensive information on aptamers. It collects thousands of aptamers obtained from SELEX-based screening in the literature and and other databases, which may facilitate biologists to develop novel aptamers and accelerate aptamer-related researches.
Aptamer
Aptamer is a short, single-stranded nucleic acid that interacts with corresponding targets with high affinity to form a unique secondary structure and three-dimensional structure of target. Its emergence provides a new research platform for efficient and rapid recognition for chemical biology and biomedicine, and shows good application prospects in many aspects.
SELEX
Systematic Evolution of Ligands by Exponential Enrichment (SELEX) technology is a newly developed combinatorial chemistry technology in the early 1990s. It can be effectively used for nucleic acid structure analysis and function research. Due to its high resolution and strong practicability, SELEX technology is widely used in in vitro diagnosis, in vivo treatment and drug development.
Data
AptaDB integrates experimental data on 1350 aptamer-target interactions connected 1293 aptamer and 436 targets. Among these targets, protein, small molecule, and cell accounts for 47.3% ,29.11% and 14%, respectively. Compared to the existing aptamer databases, aptamer-target interactions increased by nearly 123.1% and the total number of aptamers increased by nearly 113.7%.
DEV TOOL
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