"Compound ID" "Compound name" "Original SMILES" "Prepared SMILES" "Target ID" "Protein name" "Protein family" "Gene symbol" "Gene ID" Organism Score Rank 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC P48039 "Melatonin receptor type 1A (Mel-1A-R) (Mel1a receptor)" "G-protein coupled receptor 1 family" MTNR1A 4543; "Homo sapiens (Human)" 3.97804 1 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC P56817 "Beta-secretase 1 (EC 3.4.23.46) (Aspartyl protease 2) (ASP2) (Asp 2) (Beta-site amyloid precursor protein cleaving enzyme 1) (Beta-site APP cleaving enzyme 1) (Memapsin-2) (Membrane-associated aspartic protease 2)" "Peptidase A1 family" BACE1 23621; "Homo sapiens (Human)" 3.3904 2 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC Q9Y5N1 "Histamine H3 receptor (H3R) (HH3R) (G-protein coupled receptor 97)" "G-protein coupled receptor 1 family" HRH3 11255; "Homo sapiens (Human)" 2.77295 3 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC P21397 "Amine oxidase [flavin-containing] A (EC 1.4.3.4) (Monoamine oxidase type A) (MAO-A)" "Flavin monoamine oxidase family" MAOA 4128; "Homo sapiens (Human)" 2.58336 4 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC P05067 "Amyloid-beta precursor protein (APP) (ABPP) (APPI) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta A4 protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31]" "APP family" APP 351; "Homo sapiens (Human)" 2.42253 5 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC P14324 "Farnesyl pyrophosphate synthase (FPP synthase) (FPS) (EC 2.5.1.10) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Geranyltranstransferase)" "FPP/GGPP synthase family" FDPS 2224; "Homo sapiens (Human)" 2.3832 6 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC Q04844 "Acetylcholine receptor subunit epsilon" "Ligand-gated ion channel (TC 1.A.9) family, Acetylcholine receptor (TC 1.A.9.1) subfamily, Epsilon/CHRNE sub-subfamily" CHRNE 1145; "Homo sapiens (Human)" 2.35655 7 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC P29466 "Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10]" "Peptidase C14A family" CASP1 834; "Homo sapiens (Human)" 1.84164 8 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC P43681 "Neuronal acetylcholine receptor subunit alpha-4" "Ligand-gated ion channel (TC 1.A.9) family, Acetylcholine receptor (TC 1.A.9.1) subfamily, Alpha-4/CHRNA4 sub-subfamily" CHRNA4 1137; "Homo sapiens (Human)" 1.83079 9 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC P23141 "Liver carboxylesterase 1 (Acyl-coenzyme A:cholesterol acyltransferase) (ACAT) (Brain carboxylesterase hBr1) (Carboxylesterase 1) (CE-1) (hCE-1) (EC 3.1.1.1) (Cocaine carboxylesterase) (Egasyn) (HMSE) (Methylumbelliferyl-acetate deacetylase 1) (EC 3.1.1.56) (Monocyte/macrophage serine esterase) (Retinyl ester hydrolase) (REH) (Serine esterase 1) (Triacylglycerol hydrolase) (TGH)" "Type-B carboxylesterase/lipase family" CES1 1066; "Homo sapiens (Human)" 1.8014 10 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC P08172 "Muscarinic acetylcholine receptor M2" "G-protein coupled receptor 1 family, Muscarinic acetylcholine receptor subfamily, CHRM2 sub-subfamily" CHRM2 1129; "Homo sapiens (Human)" 1.78609 11 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC Q13639 "5-hydroxytryptamine receptor 4 (5-HT-4) (5-HT4) (Serotonin receptor 4)" "G-protein coupled receptor 1 family" HTR4 3360; "Homo sapiens (Human)" 1.69922 12 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC Q8TDS4 "Hydroxycarboxylic acid receptor 2 (G-protein coupled receptor 109A) (G-protein coupled receptor HM74A) (Niacin receptor 1) (Nicotinic acid receptor)" "G-protein coupled receptor 1 family" HCAR2 338442; "Homo sapiens (Human)" 1.67756 13 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC P10635 "Cytochrome P450 2D6 (EC 1.14.14.1) (CYPIID6) (Cholesterol 25-hydroxylase) (Cytochrome P450-DB1) (Debrisoquine 4-hydroxylase)" "Cytochrome P450 family" CYP2D6 1565; "Homo sapiens (Human)" 1.65573 14 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC P31645 "Sodium-dependent serotonin transporter (SERT) (5HT transporter) (5HTT) (Solute carrier family 6 member 4)" "Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family, SLC6A4 subfamily" SLC6A4 6532; "Homo sapiens (Human)" 1.64178 15 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC Q9NY33 "Dipeptidyl peptidase 3 (EC 3.4.14.4) (Dipeptidyl aminopeptidase III) (Dipeptidyl arylamidase III) (Dipeptidyl peptidase III) (DPP III) (Enkephalinase B)" "Peptidase M49 family" DPP3 10072; "Homo sapiens (Human)" 1.62289 16 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC O00748 "Cocaine esterase (EC 3.1.1.84) (Carboxylesterase 2) (CE-2) (hCE-2) (EC 3.1.1.1) (Methylumbelliferyl-acetate deacetylase 2) (EC 3.1.1.56)" "Type-B carboxylesterase/lipase family" CES2 8824; "Homo sapiens (Human)" 1.61637 17 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC Q15391 "P2Y purinoceptor 14 (P2Y14) (G-protein coupled receptor 105) (UDP-glucose receptor)" "G-protein coupled receptor 1 family" P2RY14 9934; "Homo sapiens (Human)" 1.55046 18 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC P83916 "Chromobox protein homolog 1 (HP1Hsbeta) (Heterochromatin protein 1 homolog beta) (HP1 beta) (Heterochromatin protein p25) (M31) (Modifier 1 protein) (p25beta)" CBX1 10951; "Homo sapiens (Human)" 1.4103 19 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC P22303 "Acetylcholinesterase (AChE) (EC 3.1.1.7)" "Type-B carboxylesterase/lipase family" ACHE 43; "Homo sapiens (Human)" 1.38465 Known 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC P00748 "Coagulation factor XII (EC 3.4.21.38) (Hageman factor) (HAF) [Cleaved into: Coagulation factor XIIa heavy chain; Beta-factor XIIa part 1; Coagulation factor XIIa light chain (Beta-factor XIIa part 2)]" "Peptidase S1 family" F12 2161; "Homo sapiens (Human)" 1.3078 20 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC P21452 "Substance-K receptor (SKR) (NK-2 receptor) (NK-2R) (Neurokinin A receptor) (Tachykinin receptor 2)" "G-protein coupled receptor 1 family" TACR2 6865; "Homo sapiens (Human)" 1.29957 21 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC Q99720 "Sigma non-opioid intracellular receptor 1 (Aging-associated gene 8 protein) (SR31747-binding protein) (SR-BP) (Sigma 1-type opioid receptor) (SIG-1R) (Sigma1-receptor) (Sigma1R) (hSigmaR1)" "ERG2 family" SIGMAR1 10280; "Homo sapiens (Human)" 1.26121 22 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC Q9Y5S8 "NADPH oxidase 1 (NOX-1) (EC 1.-.-.-) (Mitogenic oxidase 1) (MOX-1) (NADH/NADPH mitogenic oxidase subunit P65-MOX) (NOH-1)" NOX1 27035; "Homo sapiens (Human)" 1.22521 23 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC P05177 "Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2) (Cholesterol 25-hydroxylase) (Cytochrome P(3)450) (Cytochrome P450 4) (Cytochrome P450-P3)" "Cytochrome P450 family" CYP1A2 1544; "Homo sapiens (Human)" 1.19974 24 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC P27338 "Amine oxidase [flavin-containing] B (EC 1.4.3.4) (Monoamine oxidase type B) (MAO-B)" "Flavin monoamine oxidase family" MAOB 4129; "Homo sapiens (Human)" 1.09853 25 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC P14416 "D(2) dopamine receptor (Dopamine D2 receptor)" "G-protein coupled receptor 1 family" DRD2 1813; "Homo sapiens (Human)" 1.09063 26 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC P35354 "Prostaglandin G/H synthase 2 (EC 1.14.99.1) (Cyclooxygenase-2) (COX-2) (PHS II) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (Prostaglandin-endoperoxide synthase 2)" "Prostaglandin G/H synthase family" PTGS2 5743; "Homo sapiens (Human)" 1.07509 27 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC P18089 "Alpha-2B adrenergic receptor (Alpha-2 adrenergic receptor subtype C2) (Alpha-2B adrenoreceptor) (Alpha-2B adrenoceptor) (Alpha-2BAR)" "G-protein coupled receptor 1 family, Adrenergic receptor subfamily, ADRA2B sub-subfamily" ADRA2B 151; "Homo sapiens (Human)" 1.06051 28 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC P08684 "Cytochrome P450 3A4 (EC 1.14.14.-) (1,8-cineole 2-exo-monooxygenase) (EC 1.14.14.56) (Albendazole monooxygenase (sulfoxide-forming)) (EC 1.14.14.73) (Albendazole sulfoxidase) (CYPIIIA3) (CYPIIIA4) (Cholesterol 25-hydroxylase) (EC 1.14.14.-) (Cytochrome P450 3A3) (Cytochrome P450 HLp) (Cytochrome P450 NF-25) (Cytochrome P450-PCN1) (Nifedipine oxidase) (Quinine 3-monooxygenase) (EC 1.14.14.55) (Taurochenodeoxycholate 6-alpha-hydroxylase) (EC 1.14.14.-)" "Cytochrome P450 family" CYP3A4 1576; "Homo sapiens (Human)" 1.04999 29 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC P06276 "Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase)" "Type-B carboxylesterase/lipase family" BCHE 590; "Homo sapiens (Human)" 1.02346 30 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC P00918 "Carbonic anhydrase 2 (EC 4.2.1.1) (Carbonate dehydratase II) (Carbonic anhydrase C) (CAC) (Carbonic anhydrase II) (CA-II)" "Alpha-carbonic anhydrase family" CA2 760; "Homo sapiens (Human)" 1.00029 31 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC P11229 "Muscarinic acetylcholine receptor M1" "G-protein coupled receptor 1 family, Muscarinic acetylcholine receptor subfamily, CHRM1 sub-subfamily" CHRM1 1128; "Homo sapiens (Human)" 1.00019 32 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC P23975 "Sodium-dependent noradrenaline transporter (Norepinephrine transporter) (NET) (Solute carrier family 6 member 2)" "Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family, SLC6A2 subfamily" SLC6A2 6530; "Homo sapiens (Human)" 0.970293 33 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC Q16696 "Cytochrome P450 2A13 (EC 1.14.14.1) (CYPIIA13)" "Cytochrome P450 family" CYP2A13 1553; "Homo sapiens (Human)" 0.967131 34 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC P02708 "Acetylcholine receptor subunit alpha" "Ligand-gated ion channel (TC 1.A.9) family, Acetylcholine receptor (TC 1.A.9.1) subfamily, Alpha-1/CHRNA1 sub-subfamily" CHRNA1 1134; "Homo sapiens (Human)" 0.96041 35 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC P00915 "Carbonic anhydrase 1 (EC 4.2.1.1) (Carbonate dehydratase I) (Carbonic anhydrase B) (CAB) (Carbonic anhydrase I) (CA-I)" "Alpha-carbonic anhydrase family" CA1 759; "Homo sapiens (Human)" 0.949719 36 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC Q01959 "Sodium-dependent dopamine transporter (DA transporter) (DAT) (Solute carrier family 6 member 3)" "Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family, SLC6A3 subfamily" SLC6A3 6531; "Homo sapiens (Human)" 0.946181 37 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC P41595 "5-hydroxytryptamine receptor 2B (5-HT-2B) (5-HT2B) (Serotonin receptor 2B)" "G-protein coupled receptor 1 family" HTR2B 3357; "Homo sapiens (Human)" 0.919745 38 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC P08575 "Receptor-type tyrosine-protein phosphatase C (EC 3.1.3.48) (Leukocyte common antigen) (L-CA) (T200) (CD antigen CD45)" "Protein-tyrosine phosphatase family, Receptor class 1/6 subfamily" PTPRC 5788; "Homo sapiens (Human)" 0.892612 39 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC P35462 "D(3) dopamine receptor (Dopamine D3 receptor)" "G-protein coupled receptor 1 family" DRD3 1814; "Homo sapiens (Human)" 0.879261 40 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC Q9NUW8 "Tyrosyl-DNA phosphodiesterase 1 (Tyr-DNA phosphodiesterase 1) (EC 3.1.4.-)" "Tyrosyl-DNA phosphodiesterase family" TDP1 55775; "Homo sapiens (Human)" 0.859016 41 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC P33261 "Cytochrome P450 2C19 (EC 1.14.14.-) ((R)-limonene 6-monooxygenase) (EC 1.14.14.53) ((S)-limonene 6-monooxygenase) (EC 1.14.14.51) ((S)-limonene 7-monooxygenase) (EC 1.14.14.52) (CYPIIC17) (CYPIIC19) (Cytochrome P450-11A) (Cytochrome P450-254C) (Fenbendazole monooxygenase (4'-hydroxylating)) (EC 1.14.14.75) (Mephenytoin 4-hydroxylase)" "Cytochrome P450 family" CYP2C19 1557; "Homo sapiens (Human)" 0.716971 42 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC P18825 "Alpha-2C adrenergic receptor (Alpha-2 adrenergic receptor subtype C4) (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2CAR)" "G-protein coupled receptor 1 family, Adrenergic receptor subfamily, ADRA2C sub-subfamily" ADRA2C 152; "Homo sapiens (Human)" 0.705652 43 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC Q13507 "Short transient receptor potential channel 3 (TrpC3) (Transient receptor protein 3) (TRP-3) (hTrp-3) (hTrp3)" "Transient receptor (TC 1.A.4) family, STrpC subfamily, TRPC3 sub-subfamily" TRPC3 7222; "Homo sapiens (Human)" 0.705419 44 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC P11509 "Cytochrome P450 2A6 (EC 1.14.13.-) (1,4-cineole 2-exo-monooxygenase) (CYPIIA6) (Coumarin 7-hydroxylase) (Cytochrome P450 IIA3) (Cytochrome P450(I))" "Cytochrome P450 family" CYP2A6 1548; "Homo sapiens (Human)" 0.697422 45 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC P08913 "Alpha-2A adrenergic receptor (Alpha-2 adrenergic receptor subtype C10) (Alpha-2A adrenoreceptor) (Alpha-2A adrenoceptor) (Alpha-2AAR)" "G-protein coupled receptor 1 family, Adrenergic receptor subfamily, ADRA2A sub-subfamily" ADRA2A 150; "Homo sapiens (Human)" 0.693278 46 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC O75469 "Nuclear receptor subfamily 1 group I member 2 (Orphan nuclear receptor PAR1) (Orphan nuclear receptor PXR) (Pregnane X receptor) (Steroid and xenobiotic receptor) (SXR)" "Nuclear hormone receptor family, NR1 subfamily" NR1I2 8856; "Homo sapiens (Human)" 0.690306 47 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC P37058 "Testosterone 17-beta-dehydrogenase 3 (EC 1.1.1.64) (17-beta-hydroxysteroid dehydrogenase type 3) (17-beta-HSD 3) (Short chain dehydrogenase/reductase family 12C member 2) (Testicular 17-beta-hydroxysteroid dehydrogenase)" "Short-chain dehydrogenases/reductases (SDR) family, 17-beta-HSD 3 subfamily" HSD17B3 3293; "Homo sapiens (Human)" 0.684376 48 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC Q13936 "Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Voltage-gated calcium channel subunit alpha Cav1.2)" "Calcium channel alpha-1 subunit (TC 1.A.1.11) family, CACNA1C subfamily" CACNA1C 775; "Homo sapiens (Human)" 0.672397 49 1 Untitled COP(=O)(OC)OC=C(Cl)Cl COP(=O)(OC=C(Cl)Cl)OC Q99714 "3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (17-beta-hydroxysteroid dehydrogenase 10) (17-beta-HSD 10) (EC 1.1.1.51) (2-methyl-3-hydroxybutyryl-CoA dehydrogenase) (MHBD) (3-hydroxy-2-methylbutyryl-CoA dehydrogenase) (EC 1.1.1.178) (3-hydroxyacyl-CoA dehydrogenase type II) (Endoplasmic reticulum-associated amyloid beta-peptide-binding protein) (Mitochondrial ribonuclease P protein 2) (Mitochondrial RNase P protein 2) (Short chain dehydrogenase/reductase family 5C member 1) (Short-chain type dehydrogenase/reductase XH98G2) (Type II HADH)" "Short-chain dehydrogenases/reductases (SDR) family" HSD17B10 3028; "Homo sapiens (Human)" 0.664221 50