Information
Database of Human P450 Genetic Polymorphism
Cytochrome P450 (CYP) is the most important drug-metabolizing enzyme in human body.
It is a superfamily of different distribution and subtypes.
Unlike the substrate-special enzymes, P450 can catalyze various substrates and chemical reaction types.
90% of the metabolism charged by P450 is catalyzed by several key subtypes, including CYP3A4, 2D6, 2C19, 2C9, 1A2, 2E1 and 2B6 and so on.
It has been reported that many P450 enzymes show single nucleotide polymorphism (SNP), which brings mutation to the P450 residues.
The mutation will cause human’s abnormal reaction to drugs, such as poor metabolizer and extensive metabolizer.
So in the clinical use of drugs, doctors should consider individual difference, otherwise it may result in drug poisoning.
The premise of personalized medicine is that we can foresee the interaction between P450 polymorphism and drugs.
The database here lists the activity information of 13 important human P450 subtypes toward different substrates,
including P450 1A1, 1A2, 1B1, 2A6, 2A13, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1, 2J2, 3A4.
The activity data include Km, Vm, Kcat, IC50 and some other parameters that can reflect activity.
All the data were from reliable literatures provided by periodicals such as DMD, JPET, JMC, Mol Pharmacol.
We hope it can provide useful information for predicting drug metabolism and P450 mutation study.
