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Welcome to admetSAR
A comprehensive source and free tool for evaluating chemical ADMET properties admetSAR is free for non-commercial use only. For any other use, please contact us |
Main features
A (Absorption)
- Human intestinal absorption (HIA)
- Human oral bioavailability (HOB)
- Caco-2 permeability
- Plasma protein binding (PPB)
- P-glycoprotein substrate, inhibitor
- Blood-brain barrier penetration (BBB)
- Blood-placenta barrier (BPB)
- Cytochrome P450 (CYP450) substrate, inhibitor
- Substrate: CYP2C9, 2D6, 3A4
- Inhibitor: CYP1A2, 2D6, 2C9, 2C19, 3A4
- Pharmacokinatics transporters: BRCPi, BSEPi, OCT1i, OCT2i, MATE1i, OATP1b1i, OATP1b3i, OATP2b1i
- Half time (t1/2)
- Renal clearance
- Organ toxicity
- Drug-induced liver injury
- Human either-a-go-go-ralted gene (hERG) inhibition
- Acute toxicity
- Eye injury & Eye corrosion
- Genomic toxicity
- Ames mutagenesis
- Carcinogenesis
- Micronucleus assay
- Eco-toxicity
- Tetrahymena Pyriformis toxicity
- Phytoplankton toxicity
- Honey bee toxicity
- Avian toxicity
- Biodegradation
What is admetSAR
admetSAR creates a user-friendly interface to search for ADME/T (Absorption, Distribution, Metabolism, Excretion, and Toxicity) properties profiling by name, CASRN and similarity search. admetSAR can predict about 50 ADMET endpoints with QSAR models.
News and updates
- November 19, 2018, Corrected some mistakes and changed the cdn from bootcdn to unpkg.
- August 28, 2018, The paper of admetSAR 2.0 was published by Bioinformatics. ⇓
- July 18, 2018, The admetSAR 2.0 was released.
- October 23, 2012, The paper of admetSAR was published by J. Chem. Inf. Model.
Functions of admetSAR
PredictionadmetSAR can help researchers, PK specialists to do as follows:
- Customizable ADMET Risk filters.
- QSAR-based ADMET properties Prediction.
- Predict toxicity for environmental chemicals.
- Environmental Hazard Assessment.
ADMETopt can help researchers optimize drug leads according to the ADMET properties